130622-05-8 Tert-butoxycarbonyl-D-glutamic acid(methyl ester)-methyl ester

Fluoroquinolones ei ai alaleo antibacterial lautele, gaioiga malosi antibacterial, maualalo faʻalavelave faʻalavelave, faʻaogaina lelei o le tino, maualuga o le bioavailability oral, taimi umi o le pulega ma le faʻaogaina lelei.E masani ona faʻaaogaina i togafitiga o faʻamaʻi faʻamaʻi e pei o le manava o le manava ma le faʻamaʻi o le urinary tract.O le fausaga o vailaʻau faʻamaʻi faʻamaʻi fluoroquinolone o loʻo faʻaalia i le i ai o le fluorine i le tulaga ono o le quinolone matua nucleus.
Ae ui i lea, i le 10 tausaga talu ai nei, ona o le mamafa o le filifilia e mafua mai i le lautele o le faʻaogaina o lenei ituaiga o vailaʻau, faʻateleina faʻamaʻi faʻamaʻi, aemaise lava i tausaga talu ai nei, o le Streptococcus pneumoniae e tetee i le quinolone o loʻo i ai le faʻasagatau, lea e tetee i le penicillin, macrolide antibiotics ma quinolone antibiotics.I le taimi lava e tasi, na maua ai o nisi o fluoroquinolones e mafai ona mafua ai le faʻalauteleina o le vaeluaga o le QTc o le electrocardiogram, hepatotoxicity ma le phototoxicity, lea na faʻatapulaʻaina ai lo latou faʻaogaina.
Ina ia faʻatoʻilaloina faʻaletonu o loʻo i luga o fluoroquinolones, e faʻanatinati le atinaʻeina o mea faʻapipiʻi fou ma le gaioiga lelei o le antibacterial, lautele o alaleo antibacterial ma le laʻititi e mafai ona faʻalavelave faʻasaga i siama faʻamaʻi faʻamaʻi.O se fa'asologa o vaila'au fou e leai se fluoroquinolone (NFQ) fou e maua ai le 8-methoxyl e ese mai i vaila'au fa'ama'i fluoroquinolone e le o iai le fluorine i le tulaga 6 o le nucleus matua o le quinolone, ae o lo'o i ai pea le malosi i vitro antibacterial.nemonoxacin ose NFQ filifilia siama topoisomerase inhibitor.
Pe a faʻatusatusa i fluoroquinolones o loʻo i ai nei i luga o le maketi, o le Nenofloxacin e fai ma sui o se vasega fou o vailaʻau faʻavae.nemonocacin (TG-873870), o se vailaʻau quinolone fou na atiaʻe e Procter & Gamble (P&G), na faʻaalia ai le tele o gaioiga antibacterial e faasaga i le tele o faʻamaʻi faʻamaʻi talafeagai, e aofia ai le Staphylococcus aureus ma le multidrug-resistant Streptococcus pneumoniae.O faʻaiʻuga o le faʻataʻitaʻiga i isumu afaina na faʻaalia ai o le aʻafiaga o le antibacterial o lenei oloa na sili atu le malosi nai lo le tele o quinolones o loʻo iai nei.E le gata i lea, o le oloa o loʻo i ai uiga lelei o le pharmacokinetic ma e faʻafeiloaʻi lelei.