Saina 67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester Faumea ma Falegaosi |Jiayinglai

67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester

Fa'amatalaga Puupuu:

Fa'aaliga	Pa'epa'e ile Pa'epa'e tioata po'o le pauta tioata.
MF	C16H22N2O6
MW	338.36
Mama	98+

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Fa'amatalaga Oloa

Tulaga o felauaiga & auala fautuaina o felauaiga:
i luga o le ea, i le sami poʻo le faʻaalia

Tulaga teuina:
Faamaufa'ailoga i le mago, Temperature Room

Fa'atauga La'ititi:
Fa'atalanoaga

Fa'ailoga:
COA, HPLC, GC, HNMR, Suʻega, Suavai (KF), TLC avanoa

Synonyms

(S)-ethyl 2-(tert-butoxycarbonylaMino)-3-(4-nitrophenyl)propanoate;
Boc-(4-NO2)-L-Phe-OEt;
Boc-(4-NO2)-Oet;
Boc-Phe(4-NO2)-Oet;
L-Phenylalanine;
N-[(1,1-dimethylethoxy)carbonyl]-4-nitro-, ethyl ester

totonu afifiina

E masani ona fa'aaogaina e fa'apipi'i ai le pauta.Ma e mafai ona latou puipuia le susulu o le la ma le vai mai le leaga.

afifi i fafo

O le pusa malo e mafai ona puipuia au oloa mai le paʻu ma susu.

Talosaga

Nidanib, o se vailaʻau.Igoa kemisi 1 h - indole - 6 - carboxylic acid, 2, 3 - dihydro - 3 - [[[4 - (methyl [(4 - methyl - 1 - piperazine) acetyl] amino] phenyl] amino] benzene heartland of methyl] - 2 - okesene -, methyl ester, (z) - I le falemaʻi, o lenei oloa e faʻaaogaina e togafitia ai le idiopathic pulmonary fibrosis (IPF).
Na suʻesuʻeina e Nidanib le 1,529 tagata mamaʻi ma le idiopathic pulmonary fibrosis (IPF) i le tele o suʻesuʻega faʻapitoa.O faʻamatalaga saogalemu o loʻo tuʻuina atu e faʻavae i luga o se faʻatusatusaga o 1061 tagata maʻi na tuʻuina atu i le nidanib 150 mg faalua i aso taitasi ma le placebo i le lua 52-vaiaso vaega 3, faʻasolosolo, faʻalua-tauaso, suʻesuʻega placebo (INPULSIS-1 ma INPULSIS-2).O faʻalavelave faʻalavelave sili ona taatele e fesoʻotaʻi ma le faʻaaogaina o le nidanib e aofia ai le manava, faufau ma puaʻi, tiga o le manava, leiloa le manaʻo, paʻu o le mamafa, ma le maualuga o enzymes ate.Fa'amolemole va'ai i le [Fa'asagaga] mo le fa'atonutonuina o fa'alavelave fa'aletonu.O le Systematic Organ Classification (SOC) o le MedDRA o loʻo tuʻuina atu ai se aotelega o faʻalavelave leaga ma faʻavasegaina taimi.
O le Nidanib o se mea e fai mo P-gp (silasila i le Pharmacokinetics).I se suʻesuʻega faʻapitoa o fesoʻotaʻiga vailaʻau, tuʻufaʻatasia o le ketoconazole, o se faʻamalosi malosi P-gp, faʻateleina le faʻaalia i le nidanib i le 1.61 taimi i le vaega i lalo ole curve (AUC) ma le 1.83 taimi ile maualuga maualuga (Cmax).
I se suʻesuʻega faʻamalositino faʻatasi ma le malosi o le P-gp inducer rifampicin, o le faʻaalia i le nidanib na faʻaititia i le 50.3%, e pei ona fuaina e le vaega i lalo o le pupuni (AUC), pe a tuʻufaʻatasia ma le rifampicin pe a faʻatusatusa i le Nidanib naʻo.I le maualuga maualuga (Cmax), na faʻaititia i le 60.3%.
Pe a tu'uina fa'atasi ma lenei oloa, e mafai ona fa'atupuina le fa'aa'afia i le nidanib (eg, ketoconazole po'o le erythromycin).I nei tulaga, e tatau ona mataʻituina lelei le faʻapalepale o le tagata maʻi i le nidanib.O le puleaina o faʻalavelave faʻalavelave e ono manaʻomia ai le faʻagata, faʻaitiitia o le faʻaogaina, poʻo le faʻagataina o togafitiga ma lenei oloa (silasila i le [Faʻaaogaina ma le fua]).
P-gp potent inducers (fa'ata'ita'iga, rifampicin, carbamazepine, phenytoin ma St. John's wort) e mafai ona fa'aitiitia le a'afia i le nidanib.O isi tu'ufa'atasiga e leai pe la'ititi P-gp induction e tatau ona mafaufauina.

oloa fa'atatau

Gly-Phe	Boc-Phe-Gly-Ome	HN-Me-L-Phe.Hcl	Boc-D-Phe-D-Phe
Boc-D-4-Chloropheny(alanine)	Fmoc-L-Phe-OH	L-Phe-NH2.Hcl	Boc-Phe-Gly
L-Ala-Phe-OH	Fmoc-D-Phe-OH	4-NO2-Phe-Oet	Boc-L-Phe-Onp
Boc-Ala-Phe-OH	Fmoc-N-Me-L-Phe-OH	4-NO2-Phe-Oet.HCl	Boc-L-Phe-Oet
Boc-Ala-Phe-OH	FMOC-N-Me-D-Phe-OH	HD-Phe-OMe·HCl	Boc-4-NO2-D-Phe-OEt
Fmoc-β-Ala-D-phe	Fmoc-Phe-Cl	HL-Phe-OMe.HCl	Boc-D,L-Phe(4-NO2)-OH
Leu-Phe.Hcl	Fmoc-Phe(4-NO2)-OH	H-DL-Phe-OBzl .tos	Fmoc-Phe-Phe-OH
Boc-Leu-Phe	Cbz-L-Phe-OH	H-DL-Phe(4-NO2)-OH.H2O	Fmoc-Phe-Gly-OH
Cbz-L-Phe-Leu-OH	Cbz-D-Phe-OH	HL-Phe-OBzl.HCl	Fmoc-D-Phe(4-NO2)-OH
L-Phe	Cbz-DL-Phe-OH	HL-Phe-OEt.HCl	Cbz-Phe-Arg-OH
HD-Phe-OH	Cbz-D-Phe-OL	L-Phe-NH2	Cbz-Phe-Ala-OH
L-Phe-NCA	ZN-Me-L-Phe-OH	D-Phe-NH2	Cbz-Phe-Gly-OH
Tosi-Phe	cbz-L-Phe-OSU	N-Ac-L-Phe-OH	Cbz-Phe-Met-OH
L-Phe-ol	Fe-Ala	N-AC-L-Phe-Ome	Cbz-Phe-Gly-Oet
L-Phe（4-NO2）-OH	L-Phe-Phe	N-Pht-Phe-OH	Boc-Phe-Gly-Gly-OH
L-Phe（4-NO2）.H2O	L-Phe-Trp	Boc-Phe-OH	Fmoc-L-Thr(tBu)-Phe-OH
D-Phe(4-NO2)-OH.h2o	L-Phe-Leu-OH	Boc-D-Phe-OH	D-Phe-NH2
D-Phe(4-NO2)-OH	L-Phe-Tyr-OH	Boc-DL-Phe-OH	Tyr-Phe
N-Me-D-Phe	L-Phe-Gly	BOC-N-Me-D-Phe-OH	DL-Phe-Ome.Hcl
HN-Me-L-Phe-OH	D-Phe-D-Phe	Boc-N-Me-DL-Phe-OH	Boc-Met-Leu-Phe
L-Phe.hcl	L-Phe-OBzl-OH	Boc-N-Me-L-Phe-OH	Asp-Phe-Ome
4-NO2-D-phe.hcl	D-Phe-Obzl.Tos	Boc-N-Me-L-Phe-OH.DCHA	L-Homophe-OH
HL-Phe-OtBu.HCl	Boc-Phe-Ala-OH	Boc-DN-Me-Phe•DCHA	D-Homophe-OH
HD-Phe-OtBu.HCl	Boc-Phe-Leu-OH	Boc-Phe-Ol	L-Homophe-Oet.Hcl
D,L-Phe-OtBu HCl	Boc-Phe-Trp-OH	Boc-D-Phe-Ol	D-Homophe-Oet.HCl
HD-Phe(4-NO2)-Ome.HCl	Boc-L-Phe-Tyr-OH	Boc-Phe-NH2	Boc-L-Homophe-OH
D-Phe-Obzl.Hcl	Boc-Phe-Phe-OH	Boc-L-Phe-Ome	Boc-D-Homophe-OH
DL-Phe-Ome.Hcl	Boc-D-Phe-Phe	Boc-D-Phe-Ome	Fmoc-L-HomoPhe-OH
Boc-D-Phe(4-NO2)-OH	Cbz-D-Homophe-OH	Boc-Phe-Obzl	Fmoc-D-Homophe-OH
Boc-L-Phe-OSU	Boc-Homophe-Leu-Phe-Ome	Boc-4-NO2-Phe-OH	Cbz-L-Homophe-OH
Boc-D-Phe-OSU

Fa'asilisili

1. R&D auaunaga avanoa
2. ISO faʻamaonia le gaosiga, faʻamaonia lelei
3.O se vasega atoa o auaunaga tulitatao i le taimi o le gaosiga
4.High tau aoga
5.Quality pepa fa'amaonia e tu'uina atu ile talosaga a le tagata fa'atau
6.Great auaunaga faʻatau, tausia vavalalata vavalalata ma tagata faʻatau
7.Full punaoa e fesoasoani e faʻaitiitia tau o felauaiga
8. Free faʻataʻitaʻiga ofo atu e siaki le lelei aʻo leʻi faia soʻo se totogi
9. Totogi taimi feutagai
10. Assit tagata faʻatau e faʻatautaia mataupu i Saina